Gram Coverage: Tetracyclines cover both gram-positive and gram-negative bacteria. These drug names usually end in “cycline”. There are 5 generations of cephalosporin medications based on their spectrum of coverage.įor a simple trick to remember which medications are in each generation, check out the following EZmed post! “ Cephalosporin Generations Made Easy”įor the simple “arrow trick” to remember the coverage of each cephalosporin generation check out the following EZmed post! “ Cephalosporin Coverage Made Easy”ĭrug Names: Examples of tetracyclines include tetracycline and doxycycline. As a result, the bacterial cell wall is disrupted.Įxample Indications: Cephalosporins can be used for skin, urinary, and respiratory infections among others. Peptidoglycan synthesis is facilitated by penicillin-binding proteins (PBPs).Ĭephalosporins (along with penicillins and carbapenems) contain a beta-lactam ring in their structure and are classified as beta-lactam antibiotics as a result.īeta-lactam antibiotics bind to, and inhibit, PBPs thereby preventing peptidoglycan synthesis and cross-linking. Peptidoglycan is a major component of bacterial cell walls and is necessary to maintain the cell wall integrity. Mechanism of Action: Cephalosporins inhibit cell wall synthesis. Gram Coverage: Cephalosporins cover both gram-positive and gram-negative bacteria. These drug names typically begin with “cef/ceph”. Aminoglycosides bind to the 30s ribosomal subunit of bacteria thereby disrupting protein synthesis (human ribosomes have a 40s and 60s subunit and are not affected by the antibiotic as a result).Įxample Indications: Aminoglycosides are highly potent, broad-spectrum antibiotics and can be used for bacteremia, intra-abdominal infections, and other life-threatening infections that may progress to shock if untreated.ĭrug Names: Examples of cephalosporins include ceftriaxone and cefepime.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |